

Date: 11 March 2025 (Tuesday)
Time: 11am (GMT+1)
The webinar is intended for scientists and researchers working with cell and tissue cultures who want to expand their knowledge in the field of brain organoids or plan to start research using these models. During the meeting, the Host will briefly present the current state of knowledge on brain organoids, discuss the methodology of their cultivation and present the applications of these models in scientific research. Particular attention will be paid to the practical aspects of working with organoids and their potential in neurobiological and neurological research.
The webinar will be led by Sandra Acosta, PhD, Assistant Professor, who has extensive experience in the field of brain organoids derived from iPSC/ESC and their use in modeling genetic and neurodevelopmental diseases. Dr. Acosta is a Serra-Hunter Fellow and Assistant Professor in the Department of Pathology and Experimental Therapeutics at the University of Barcelona. Throughout her career, she has been working on issues related to the development of the central nervous system (CNS), developing models (both in vitro and in vivo) of brain development – in health and in disease. During her PhD, she had the opportunity to work on the 3D culture of tumoroids. She completed two postdoctoral internships – the first in the laboratory of prof. Vanderhaeghen in Brussels (2009-2013), the second in the laboratory of prof. Oliver at Northwestern University in Chicago (2014-2018).
Her team’s research focuses on solving key questions related to the development of the human brain in health and disease. Thanks to an interdisciplinary approach – her team has developed not only several tools – from genomics to technologically advanced AI, but also made significant contributions to understanding the pathomechanisms related to developmental epilepsy, Alzheimer’s disease, as well as understanding how the most human features of the brain are formed in evolution.
Sandra Acosta, PhD, Assistant Professor about herself:
As a scientist, I have a long trajectory in the fields of iPSC/ESC-derived brain organoids and genetic and neurodevelopmental disease modeling. I am Serra-Hunter Fellow and Assistant Professor at Department of Pathology and Experimental Therapeutics, University of Barcelona (April 2021). Throughout my career, I tackled questions related to the development of the central nervous system implementing in vitro and in vivo models of brain development in health and disease. Briefly, during my PhD, I got the chance to receive an early introduction and work with culture of 3D tumoroids (then called Neurospheres). Next, I expanded my international profile during two postdoctoral fellowships in the lab of Prof. Pierre Vanderhaeghen in Brussels (2009-2013) and Prof. Oliver at Northwestern University in Chicago (2014- 2018).
My lab is centered in understanding central questions of human brain development in health and disease. To this purpose, we tackle our questions from a multidisciplinary perspective. This approach lead us to developing several tools, from a genomics and technological AI perspective, and to contribute to the pathogenesis associated to developmental epilepsy, Alzheimer disease, as well as to understand how the human-most brain traits arise evolutionary.
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The Foundation for the Promotion of Science and Development 'TYGIEL’ was established in 2014. Since its inception, it has been the initiator and organizer of numerous scientific conferences, as well as educational and research-based events. As a dynamic scientific organization dedicated to promoting research and knowledge exchange, we focus on:
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